Gene: F58A4.3
F58A4.3 | SMap | S_parent | Sequence | F58A4 | ||
---|---|---|---|---|---|---|
Chromosome | III | |||||
Identity (5) | ||||||
Gene_info | Gene_class | hcp | ||||
GO_term (10) | ||||||
Structured_description | Provisional_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. | Paper_evidence | WBPaper00004736 | ||
Person_evidence | WBPerson567 | |||||
Curator_confirmed | WBPerson567 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
Concise_description | The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos. | |||||
Molecular_info (5) | ||||||
Experimental_info | RNAi_result (5) | |||||
WB_RNAi_result | TH:335f3 | |||||
[cgc4544]:hcp-3 | ||||||
[cgc4736]:hcp-3 | ||||||
JA:F54C8.2 | ||||||
JA:F58A4.3 | ||||||
[cgc5322]:hcp-3 | ||||||
[cgc5264]:hcp-3 | ||||||
Simmer:F54C8.2 | ||||||
Simmer:F58A4.3 | ||||||
MV_SV:mv_G_YK2579_1 | ||||||
Cenix:322-d11 | ||||||
Cenix:335-f3 | ||||||
Cenix:175-b7 | ||||||
Expr_pattern (5) | ||||||
Gene_regulation | Trans_regulator | cgc4735_hcp-1_b | ||||
cgc4735_hcp-4 | ||||||
Trans_target | cgc4735_hcp-3 | |||||
Y2H_target | Y2H007532 | |||||
Reference | WBPaper00004544 | |||||
WBPaper00005322 | ||||||
WBPaper00003702 | ||||||
WBPaper00005142 | ||||||
WBPaper00005173 | ||||||
WBPaper00006142 | ||||||
WBPaper00017716 | ||||||
WBPaper00017717 | ||||||
WBPaper00017877 | ||||||
WBPaper00005178 | ||||||
WBPaper00024319 | ||||||
WBPaper00024405 | ||||||
WBPaper00018629 | ||||||
WBPaper00017715 | ||||||
Remark | Sequence connection from [Moore LL, Roth MB]. krb 13/11/01 | |||||
Method | Gene |