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Gene: F58B6.3   

F58B6.3SMapS_parentSequenceF58B6
ChromosomeIII
Identity (5)
Gene_info Gene_classpar
Allele e2030
it5 Inferred_automaticallyFrom strain object: KK114
it46 Inferred_automatically From strain object: JR1763
From strain object: LV15
From strain object: LV18
From strain object: LV19
lw32
n17
Phenotype it46ts mat : homozygous hermaphrodites produce 90% (16x) to 99% (25x) arrested embryos escapers sterile; abnormal early cleavages defective P granule localization. ES3 (progeny). NA4 (it5ts : weaker phenotype e2030 : grandchildless).
See also e2030
[C.elegansII] it46ts,mat : homozygous hermaphrodites produce 90% (16C) to 99% (25C) arrested embryos, escapers sterile; abnormal early cleavages, both spindles transverse at 2nd cleavage (failure of P1 rotation), defective P granule localization. ES3 (progeny). OA7: it5ts (weaker phenotype), e2030 (Mes, grandchildless),it87 (weak),jb2, etc. All ts; temp shift indicates not needed after 2nd cleavage. Cloned: encodes predicted novel protein. Antibody staining indicates specific asymmetric cortical localizations in early blastomeres. [Cheng et al. 1995; KK]
Strain (5)
GO_term (9)
Contained_in_operonCEOP3056
Structured_description Provisional_description (6)
Concise_descriptionpar-2 encodes a protein containing a C3HC4-type RING-finger, a specialized type of zinc-finger found in E3 ubiquitin ligase subunits; PAR-2 is required maternally for polarization of the C. elegans zygote along the anterior-posterior (A-P) axis and is asymmetrically localized to the posterior cortex of the one- and two-cell embryo via interdependent interactions with PAR-3, PAR-6, and PKC-3.
Molecular_info Corresponding_CDS F58B6.3a
F58B6.3b
Corresponding_protein WP:CE25917
WP:CE31016
Corresponding_PCR_product smd_F58B6.3
smd_F58B6.3:2
sjj_F58B6.3
Corresponding_RNAi_reagent (5)
Experimental_info (5)
Reference (178)
MethodGene