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Gene: H25P06.2   

H25P06.2SMapS_parentSequenceSUPERLINK_CB_IR
ChromosomeI
Identity (5)
Gene_info Gene_classcdk
Allele (5)
GO_term (5)
Structured_description Provisional_description cdk-9 encodes an ortholog of the metazoan transcription elongation factor kinase CDK-9; it is required for general expression of early embryonic genes, and thought (in conjunction with partners such as cyclin T) to form a transcription factor (P-TEFb) that which prevents transcription from stalling in vitro. Paper_evidence WBPaper00004192
WBPaper00005411
WBPaper00012800
Person_evidenceWBPerson567
Curator_confirmedWBPerson567
Date_last_updated17 Jun 2004 00:00:00
Heat shock genes are rendered independent of CDK-9 when not only cdk-9, but also spt-4 and spt-5 are inhibited by RNAi, implying that SPT-4/SPT-5 antagonize CDK-9 function in vivo.
CDK-9 is required for phosphorylation of the Ser-2 residue of the RNA Polymerase II C-terminal domain (CTD) repeat, but not for most CTD Ser-5 phosphorylation.
Concise_descriptioncdk-9 encodes an ortholog of the metazoan transcription elongation factor kinase CDK-9; it is required for general expression of early embryonic genes, and thought (in conjunction with partners such as cyclin T) to form a transcription factor (P-TEFb) that which prevents transcription from stalling in vitro.
Molecular_info (6)
Experimental_info RNAi_result JA:H25P06.2a
Simmer:H25P06.2a:Screen_A
Simmer:H25P06.2a:Screen_B
Cenix:118-b11
WB_RNAi_result (5)
InteractionWBInteraction0003603
Reference (6)
MethodGene