R05F9.8 | SMap | S_parent | Sequence | R05F9
|
| Chromosome | II |
|
Identity (5)
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Gene_info
| Gene_class | msp
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| | Phenotype | [C.elegansII] NMK. Encodes MSP (16kD); msp-152 cluster. [Ward et al. (1988); BA] |
| | GO_term | GO:0005198
| IEA
| Inferred_automatically |
| |
Structured_description
| Provisional_description | msp-33 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-33 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. |
Paper_evidence
| WBPaper00001023
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| | | | | | WBPaper00002143
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| | | | | | WBPaper00004280
|
| | | | | | WBPaper00004591
|
| | | | | | WBPaper00005670
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| | | | | Curator_confirmed | WBPerson324
|
| | | | | Date_last_updated | 06 May 2005 00:00:00 |
| | | Concise_description | msp-33 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; msp-33 has a C. briggsae homolog as predicted by the Wobble Aware Bulk Aligner (WABA); the MSP family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. |
|
Molecular_info
| Corresponding_CDS | R05F9.8
|
| | Corresponding_protein | WP:CE04811
|
| |
Corresponding_PCR_product (54)
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Corresponding_RNAi_reagent (56)
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Experimental_info
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RNAi_result (6)
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WB_RNAi_result (72)
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| | Expr_pattern | Expr3417
|
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Reference
| WBPaper00001023
|
| | WBPaper00015440
|
| | WBPaper00025088
|
| Method | Gene
|