Gene: T14A8.1
T14A8.1 | Evidence | CGC_data_submission | ||||
---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T14A8 | |||
Chromosome | IV | |||||
Identity (5) | ||||||
Gene_info | Gene_class | ric | ||||
Allele | hm9 | Inferred_automatically | From strain object: MF200 | |||
hm19 | ||||||
hm54 | ||||||
hm65 | ||||||
md146 | ||||||
md156 | ||||||
md158 | Inferred_automatically | From strain object: RM509 | ||||
md226 | ||||||
md1181 | ||||||
Phenotype (2) | ||||||
Strain | MF200 | |||||
RM509 | ||||||
Structured_description | Provisional_description | The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor. | Paper_evidence | WBPaper00005151 | ||
Person_evidence | WBPerson567 | |||||
Curator_confirmed | WBPerson567 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
However, GABA and glutamate receptors, despite being coexpressed with ric-3-dependent nicotinic acetylcholine receptors, are unaffected by mutation of ric-3. | ||||||
Mutations in ric-3 mutants are resistant to inhibitors of cholinesterase and suppress neurodegeneration caused by a gain-of-function deg-3 mutation. | ||||||
Coexpression of ric-3 in Xenopus laevis oocytes enhances the activity of the C.elegans DEG-3/DES-2 and of the rat alpha-7 acetylcholine receptors. | ||||||
Concise_description | The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor. | |||||
Molecular_info (4) | ||||||
Experimental_info | RNAi_result (5) | |||||
WB_RNAi_result | SA:yk266d12 | |||||
JA:T14A8.1 | ||||||
[cgc5655]:T14A8.1 | ||||||
[cgc5655]:tph-1:T14A8.1 | ||||||
[cgc5655]:tub-1:T14A8.1 | ||||||
MV_SV:mv_G_YK5056 | ||||||
Cenix:105-c4 | ||||||
Expr_pattern | Expr1841 | |||||
Interaction | WBInteraction0001603 | |||||
WBInteraction0001604 | ||||||
WBInteraction0001898 | ||||||
WBInteraction0002829 | ||||||
Reference (14) | ||||||
Remark | previously appeared as des-5 | |||||
Sequence connection from [Halevi S, Treinin M] | ||||||
Method | Gene |