Gene: T14A8.1
T14A8.1 | Evidence | CGC_data_submission | ||||
---|---|---|---|---|---|---|
SMap | S_parent | Sequence | T14A8 | |||
Chromosome | IV | |||||
Identity (5) | ||||||
Gene_info | Gene_class | ric | ||||
Allele (9) | ||||||
Phenotype (2) | ||||||
Strain (2) | ||||||
Structured_description | Provisional_description | The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor. | Paper_evidence | WBPaper00005151 | ||
Person_evidence | WBPerson567 | |||||
Curator_confirmed | WBPerson567 | |||||
Date_last_updated | 17 Jun 2004 00:00:00 | |||||
However, GABA and glutamate receptors, despite being coexpressed with ric-3-dependent nicotinic acetylcholine receptors, are unaffected by mutation of ric-3. | ||||||
Mutations in ric-3 mutants are resistant to inhibitors of cholinesterase and suppress neurodegeneration caused by a gain-of-function deg-3 mutation. | ||||||
Coexpression of ric-3 in Xenopus laevis oocytes enhances the activity of the C.elegans DEG-3/DES-2 and of the rat alpha-7 acetylcholine receptors. | ||||||
Concise_description | The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor. | |||||
Molecular_info (4) | ||||||
Experimental_info (4) | ||||||
Reference | WBPaper00015580 | |||||
WBPaper00002590 | ||||||
WBPaper00017986 | ||||||
WBPaper00023190 | ||||||
WBPaper00002195 | ||||||
WBPaper00002297 | ||||||
WBPaper00005594 | ||||||
WBPaper00005687 | ||||||
WBPaper00018129 | ||||||
WBPaper00023449 | ||||||
WBPaper00006324 | ||||||
WBPaper00025141 | ||||||
WBPaper00025716 | ||||||
WBPaper00026764 | ||||||
Remark (2) | ||||||
Method | Gene |