T14A8.1 | Evidence | CGC_data_submission |
| SMap | S_parent | Sequence | T14A8
|
| Chromosome | IV |
|
Identity
| Version | 1 |
| |
Name (7)
|
| | Species | Caenorhabditis elegans
|
| | History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971
| Event | Imported | Initial conversion from geneace |
| | Status | Live |
|
Gene_info
| Gene_class | ric
|
| |
Allele (9)
|
| |
Phenotype
| [Rand JB] Unc, small, slow growing, resistant to cholinesterase inhibitors |
| | | [M Treinin] suppression of deg-3(u662) induced degenerations, Coilers, Levamisole resistance, Aldicarb resistance, pharyngeal pumping defect, temperature sensitive growth |
| |
Strain
| MF200
|
| | | RM509
|
| |
Structured_description
|
Provisional_description
| The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor. | Paper_evidence | WBPaper00005151
|
| | | | | Person_evidence | WBPerson567
|
| | | | | Curator_confirmed | WBPerson567
|
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | | However, GABA and glutamate receptors, despite being coexpressed with ric-3-dependent nicotinic acetylcholine receptors, are unaffected by mutation of ric-3. |
| | | | Mutations in ric-3 mutants are resistant to inhibitors of cholinesterase and suppress neurodegeneration caused by a gain-of-function deg-3 mutation. |
| | | | Coexpression of ric-3 in Xenopus laevis oocytes enhances the activity of the C.elegans DEG-3/DES-2 and of the rat alpha-7 acetylcholine receptors. |
| | | Concise_description | The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor. |
|
Molecular_info
| Corresponding_CDS | T14A8.1
|
| | Corresponding_protein | WP:CE27448
|
| |
Corresponding_PCR_product
| smd_T14A8.1
|
| | | sjj_T14A8.1
|
| |
Corresponding_RNAi_reagent
| Cenix:105-c4
|
| | | sjj_T14A8.1
|
| | | yk266d12
|
| | | mv_G_YK5056
|
|
Experimental_info
|
RNAi_result
| Cenix:105-c4
|
| | | JA:T14A8.1
|
| | | [cgc5655]:T14A8.1
|
| | | [cgc5655]:tph-1:T14A8.1
|
| | | [cgc5655]:tub-1:T14A8.1
|
| |
WB_RNAi_result
| SA:yk266d12
|
| | | JA:T14A8.1
|
| | | [cgc5655]:T14A8.1
|
| | | [cgc5655]:tph-1:T14A8.1
|
| | | [cgc5655]:tub-1:T14A8.1
|
| | | MV_SV:mv_G_YK5056
|
| | | Cenix:105-c4
|
| | Expr_pattern | Expr1841
|
| |
Interaction
| WBInteraction0001603
|
| | | WBInteraction0001604
|
| | | WBInteraction0001898
|
| | | WBInteraction0002829
|
|
Reference (14)
|
|
Remark (2)
|
| Method | Gene
|