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RNAi: TH:300c6   

Experiment LaboratoryTH
Author Gonczy P
Echeverri C
Oegema K
Coulson AR
Jones SJ
Copley RR
Duperon J
Oegema J
Brehm M
Cassin E
Hannak E
Kirkham M
Pichler SC
Flohrs K
Go essen A
Leidel S
Alleaume AM
Martin C
Ozlu N
Bork P
Hyman AA
Date16 Nov 2000 00:00:00
Inhibits (5)
Remark Phenotype comment -- Confirmed with independent dsRNA (C36E8.5-RNA2; similar phenotype). Phenotype could potentially be due to cross-RNAi inhibition of other tubulin genes (see BLASTN results). We note, however, that RNAi directed specifically against one other tubulin gene on chromosome III (C54C6.2; ben-1) failed to give rise to a phenotype, suggesting that the phenotype noted here may truly reflect a requirement for C36E8.5 function.
DIC phenotype -- Lack of male pronuclear migration; female pronucleus is located initially towards center of embryo or next to male pronucleus; sometimes 2 female pronuclei; female pronuclei drift towards male pronucleus; no bipolar spindle assembly.
All embryos dead
Results PhenotypeEmb
Phenotype_summary (7)