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Gene: ZK1248.6   

ZK1248.6SMapS_parentSequenceZK1248
ChromosomeII
Identity (5)
Gene_info Gene_classmsp
Phenotype[C.elegansII] NMK. Pseudogene for MSP; msp-142 cluster. [Ward et al. (1988); BA]
GO_termGO:0005198 IEA Inferred_automatically
Structured_description Provisional_descriptionmsp-64 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes. Paper_evidence WBPaper00001023
WBPaper00002143
WBPaper00004591
WBPaper00005670
Curator_confirmedWBPerson324
Date_last_updated31 Mar 2005 00:00:00
Concise_descriptionmsp-64 encodes a protein that belongs to a family of proteins called the Major Sperm Proteins (MSPs) that is conserved in nematodes; this family consists of closely related, small, basic proteins that make up 15% of sperm protein; this multigene family consists of over fifty genes, including many pseudogenes; MSPs are involved in both extracellular signaling and cytoskeletal functions during reproduction-MSP antagonizes Eph/ephrin signaling, in part, by binding VAB-1 Eph receptor tyrosine kinase on oocytes and sheath cells to promote oocyte maturation and MAPK activation; MSPs assemble into fibrous networks that drive movement of the C. elegans sperm; msp genes are expressed only in late primary spermatocytes.
Molecular_info Corresponding_CDSZK1248.6
Corresponding_proteinWP:CE02806
Corresponding_PCR_product (24)
Corresponding_RNAi_reagent Cenix:13-c7
sjj_ZK1248.6
mv_ZK354.4
sjj_ZK354.11
Cenix:14-e7
sjj_C34F11.4
sjj_ZK354.1
mv_C34F11.4
sjj_F36H12.7
mv_K05F1.7
mv_ZK1248.6
yk307d11
mv_F36H12.7
yk380e3
Cenix:242-c6
Cenix:206-e1
Cenix:242-h2
sjj_R05F9.13
Cenix:245-g4
Cenix:13-f11
sjj_ZK1248.17
Cenix:13-d7
mv_ZK1248.17
sjj_K05F1.7
sjj_R13H9.4
sjj_ZK354.5
mv_K05F1.2
Cenix:211-b4
sjj_ZK354.4
Experimental_info RNAi_result (2)
WB_RNAi_result (64)
Expr_patternExpr3417
Reference WBPaper00024312
WBPaper00025088
MethodGene