AB aster resembles P1 aster (Char: Piano_EE:40 ) Osmotic sensitivity (Char: Cenix_EE:2 ) AB nuclear migration abnormal (Char: Cenix_EE:24 ) Osmotically/ pressure sensitive (Char: Piano_EE:3 ) AB or P1 spindle orientation aberrant Other (Char: Cenix_EE:45 ) AB spindle orientation abnormal (Char: Cenix_EE:30 ) Overall pace of events slow (Char: Cenix_EE:42 ) ABa, ABp and EMS divide synchronously (Char: Piano_EE:42 ) P0 cortical ruffling abnormal (Char: Cenix_EE:3 ) Aberrant AB or P1 spindle orientation (Char: Piano_EE:37 ) P0 cytokinesis: completion/stability abnormal (Char: Cenix_EE:22 ) Aberrant cell-cell contacts at the four-cell stage (Char: Piano_EE:41 ) P0 cytokinesis: furrow ingression abnormal (Char: Cenix_EE:21 ) Aberrant Cytoplasmic Structures P0 cytokinesis: furrow specification abnormal (Char: Cenix_EE:20 ) Aberrant nuclear reassembly (Char: Piano_EE:33 ) P0 cytoplasmic flows reduced/absent (Char: Cenix_EE:4 ) Abnormal blebbing P0 pronuclear centration absent (Char: Cenix_EE:11 ) Abnormal one-cell shape (Char: Piano_EE:11 ) P0 pronuclear envelope breakdown delayed (Char: Cenix_EE:13 ) Abnormal pronuclei P0 pronuclear meeting position abnormal (Char: Cenix_EE:10 ) Abnormal size of pronucleus (Char: Piano_EE:20 ) P0 pronuclear migration reduced/absent (female) (Char: Cenix_EE:8 ) Abs P0 pronuclear migration reduced/absent (male) (Char: Cenix_EE:9 ) Altered cell-cell contacts P0 pronuclear rotation (Char: Cenix_EE:12 ) Altered timing of second division P0 pronuclei: number abnormal (Char: Cenix_EE:7 ) Altered timing of second division (synchrony) P0 pronuclei: size/shape abnormal (Char: Cenix_EE:6 ) Areas devoid of yolk granules (Char: Cenix_EE:39 ) P0 pseudo-cleavage furrow abnormal (Char: Cenix_EE:5 ) Asymmetry of Division abnormal P0 spindle absent (Char: Piano_EE:27 ) Catastrophic one-cell arrest (Char: Piano_EE:5 ) P0 spindle assembly: bipolarity abnormal (Char: Cenix_EE:14 ) Centrosome Attachment abnormal P0 spindle does not rotate (Char: Piano_EE:28 ) Chromosome Segregation (karyomeres) abnormal P0 spindle elongation abnormal (Char: Cenix_EE:16 ) Complex Phenotype P0 spindle integrity abnormal (Char: Cenix_EE:15 ) Cortical Dynamics abnormal P0 spindle poles abnormal (Char: Cenix_EE:19 ) Cpa P0 spindle positioning defect (Char: Piano_EE:26 ) Cyk P0 spindle positioning problems Cytokinesis defect (Char: Piano_EE:31 ) P0 spindle positioning problems (posterior) Cytokinesis problems P0 spindle positioning: asymmetry abnormal (Char: Cenix_EE:18 ) Delayed at pronuclear contact (Char: Piano_EE:14 ) P0 spindle rocking abnormal (Char: Cenix_EE:17 ) Delayed P0 spindle rotation (Char: Piano_EE:29 ) P1 aster abnormal (Char: Piano_EE:39 ) Delayed P1 division P1 nuclear migration/rotation absent/reduced (Char: Cenix_EE:28 ) Division axis of ABa or ABp aberrant (Char: Piano_EE:38 ) P1/AB asynchrony of divisions abnormal (Char: Cenix_EE:31 ) Dramatic cytoplasmic blebbing P1/AB cortical activity exaggerated (Char: Cenix_EE:25 ) Ectopic cleavage furrows (Char: Piano_EE:8 ) P1/AB cytokinesis abnormal (Char: Cenix_EE:32 ) Ectopic furrows P1/AB nuclear separation: cross-eyed (Char: Cenix_EE:23 ) Egg shape/size abnormal (Char: Cenix_EE:1 ) P1/AB nuclei: number abnormal (Char: Cenix_EE:26 ) Egg Size abnormal P1/AB nuclei: size/shape abnormal (Char: Cenix_EE:27 ) Embryos arrest at different stages P1/AB spindle assembly abnormal (Char: Cenix_EE:29 ) EMS divides after and is smaller than P2 (Char: Piano_EE:43 ) P2 and EMS divide synchronously (Char: Piano_EE:44 ) EMS divides before and is smaller than P1 Pace of P-Lineage abnormal EMS extends too far anteriorly (Char: Piano_EE:47 ) Passage Through Meiosis defective EMS fails to extend anteriorly (Char: Piano_EE:46 ) Paternal pronucleus migrates (Char: Piano_EE:22 ) Entry Into Interphase abnormal Pna Exaggerated asynchrony (Char: Piano_EE:34 ) Pnm Exaggerated pseudocleavage (Char: Piano_EE:13 ) Polar bodies abnormal (Char: Piano_EE:15 ) Excessive blebbing (Char: Piano_EE:7 ) Polar body reabsorbed (Char: Piano_EE:16 ) Failure to form pronucleus (Char: Piano_EE:21 ) Prm Four-cell stage configuration abnormal (Char: Cenix_EE:35 ) Pronuclear breakdown asynchronous (Char: Piano_EE:23 ) Four-cell stage nuclei: size/shape abnormal (Char: Cenix_EE:34 ) Pronuclear migration defects Four-cell stage: cross-eyed (Char: Cenix_EE:33 ) Pronuclear/Nuclear Appearance abnormal Granular cytoplasm Pronuclei can meet centrally Inadequate test (Char: Cenix_EE:46 ) Pronuclei fail to migrate (Char: Piano_EE:24 ) Indistinct maternal pronucleus (Char: Piano_EE:17 ) Pronuclei meet more centrally (Char: Piano_EE:25 ) Integrity of Membranous Organelles defective Pseudocleavage absent (Char: Piano_EE:12 ) Large cytoplasmic granules (Char: Piano_EE:6 ) Pseudocleavage problems Loose mitotic furrow (Char: Piano_EE:30 ) Reversed asynchrony (Char: Piano_EE:35 ) Loose spindle Rot Mei Severe Pleiotropic Defects Meiotic arrest (Char: Cenix_EE:44 ) Sister Chromatid Separation abnormal (Cross-eyed) Mul Slow cell cycle (Char: Piano_EE:10 ) Multiple cavities (Char: Piano_EE:9 ) Small embryos (Char: Piano_EE:4 ) Multiple maternal pronuclei (Char: Piano_EE:18 ) Spd Multiple nuclei Spi Multiple nuclei in 1, 2, or 4-cell embryos (Char: Piano_EE:32 ) Spindle Assembly abnormal Multiple paternal pronuclei or aberrant centrosomes (Char: Piano_EE:19 ) Spindle Elongation/Integrity abnormal Multiple vacuoles Spindle positioning problems Nmo Spn Npo Spo Nuclear Appearance abnormal Synchronous second division (Char: Piano_EE:36 ) Nuclei reform next to cell division remnant (Char: Piano_EE:45 ) Tetrapolar spindle (Char: Cenix_EE:36 ) Number/age of embryos atypical (Char: Cenix_EE:43 ) Unclear: multinucleate (Char: Cenix_EE:41 ) Ocs Yolk granules: density reduced (Char: Cenix_EE:37 ) Oma Yolk granules: size abnormal (Char: Cenix_EE:38 ) Osmotic Integrity defective